QT length during methadone maintenance treatment: gene × dose interaction

Dose-Dependent Effects of Methadone on QT interval in Patients under Methadone Maintenance Treatment

Background: The role of methadone in QTc prolongation, Torsades de Pointes (TdP) arrhythmia and sudden cardiac death has been debated. Because of widespread use of methadone in methadone maintenance treatment (MMT) centers, we aimed to study dose-related effects of methadone on QTc prolongation. Methods: In a comparative observational study, 90 patients who were under MMT were evaluated. Patien...

dose-dependent effects of methadone on qt interval in patients under methadone maintenance treatment

background: the role of methadone in qtc prolongation, torsades de pointes (tdp) arrhythmia and sudden cardiac death has been debated. because of widespread use of methadone in methadone maintenance treatment (mmt) centers, we aimed to study dose-related effects of methadone on qtc prolongation. methods: in a comparative observational study, 90 patients who were under mmt were evaluated. patien...

QT Prolongation and Arrhythmia Risk in Methadone Maintenance Treatment

Methadone maintenance therapy (MMT) is the most widely prescribed and most effective treatment for opioid dependence. Methadone is a long-acting synthetic opioid that is a potent blocker of the delayed rectifier potassium ion channel, which may result in QT interval prolongation (QTP) and increased risk of torsades de pointes (TdP) in susceptible individuals. MMT-associated TdP is rare; however...

Methadone maintenance treatment.

Association between methadone dose and concomitant cocaine use in methadone maintenance treatment: a register-based study

BACKGROUND Concomitant cocaine use is a major problem in clinical practice in methadone maintenance treatment (MMT) and may interfere with successful treatment. Data from European methadone populations is sparse. This register-based study sought to explore the association between prescribed methadone dose and concomitant cocaine and heroin use in the methadone population of Basel City. METHOD...